A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis
نویسندگان
چکیده
منابع مشابه
Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer.
Both Glis, the downstream effectors of hedgehog signaling, and Zic transcription factors are required for Myf5 expression in the epaxial somite. Here we demonstrate a novel synergistic interaction between members of both families and Pax3, a paired-domain transcription factor that is essential for both myogenesis and neural crest development. We show that Pax3 synergizes with both Gli2 and Zic1...
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Zic2 controls cerebellar development in cooperation with Zic1.
Mouse Zic genes encode zinc finger proteins and are expressed in the developing and mature CNS. Reduced expression of Zic2 in mice results in spina bifida and holoprosencephaly. However, the disruption of Zic1, a strong homolog of Zic2 that has an overlapping expression pattern, results in cerebellar malformation with no apparent abnormalities in the forebrain or in posterior neuropore closure....
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15 صفحه اولTwo cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.
In skeletal muscle development, the myogenic regulatory factors myf5 and myoD play redundant roles in the specification and maintenance of myoblasts, whereas myf6 has a downstream role in differentiating myocytes and myofibers. It is not clear whether the redundancy between myf5 and myoD is within the same cell lineage or between distinct lineages. Using lineage tracing and conditional cell abl...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2011
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2010.12.037